The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

Although the vast majority of women encounters at least one vaginal infection during their life, amount microbiome-related research performed in this area lags behind compared to alternative niches such as intestinal tract. As a result, effective means diagnosis and treatment, especially recurrent infections, are limited. The role metabolome health is largely elusive. It has been shown that lactate produced by numerous lactobacilli present promotes limiting chance infection. Short chain fatty acids (SCFA) have mainly linked dysbiosis, although causality relationship still under debate. In review, we aim bring together information on microbiome infections caused Candida . Vulvovaginal candidiasis affects near 70% all once life with significant proportion suffering from variant. We assess acid metabolites, SCFA lactate, onset virulence fungal pathogen. addition, pinpoint where lack limits our understanding molecular processes involved restricts possibility developing novel treatment strategies.